Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX

Abstract Background Hypoxia in the tumor microenvironment (TME) is often the main factor in the cancer progression. Moreover, low levels of oxygen in tumor tissue may signal that the first- or second-line therapy will not be successful. This knowledge triggers the inevitable search for different kin...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris, Jaromir Pastorek
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-02-01
Serie:	Cancer & Metabolism
Soggetti:	Carbonic anhydrase IX Hypoxia Humanized antibody Tumor microenvironment
Accesso online:	https://doi.org/10.1186/s40170-022-00279-8
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!