Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX

Abstract Background Hypoxia in the tumor microenvironment (TME) is often the main factor in the cancer progression. Moreover, low levels of oxygen in tumor tissue may signal that the first- or second-line therapy will not be successful. This knowledge triggers the inevitable search for different kin...

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Egile Nagusiak:	Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris, Jaromir Pastorek
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2022-02-01
Saila:	Cancer & Metabolism
Gaiak:	Carbonic anhydrase IX Hypoxia Humanized antibody Tumor microenvironment
Sarrera elektronikoa:	https://doi.org/10.1186/s40170-022-00279-8
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