CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia

Tumor hypoxia represents a severe microenvironmental stress that is frequently associated with acidosis. Cancer cells respond to these stresses with changes in gene expression that promote survival at least in part through pH regulation and metabolic reprogramming. Hypoxia-induced carbonic anhydrase...

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Bibliografske podrobnosti

Principais autores:	Martin Benej, Eliska Svastova, Radivojka Banova, Juraj Kopacek, Adriana Gibadulinova, Martin Kery, Simona Arena, Andrea Scaloni, Monica Vitale, Nicola Zambrano, Ioanna Papandreou, Nicholas C. Denko, Silvia Pastorekova
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2020-09-01
Serija:	Frontiers in Oncology
Teme:	carbonic anhydrase IX hypoxia pH regulation glycolysis metabolism
Online dostop:	https://www.frontiersin.org/article/10.3389/fonc.2020.01462/full
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