Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX

Abstract Background Hypoxia in the tumor microenvironment (TME) is often the main factor in the cancer progression. Moreover, low levels of oxygen in tumor tissue may signal that the first- or second-line therapy will not be successful. This knowledge triggers the inevitable search for different kin...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris, Jaromir Pastorek
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-02-01
coleção:	Cancer & Metabolism
Assuntos:	Carbonic anhydrase IX Hypoxia Humanized antibody Tumor microenvironment
Acesso em linha:	https://doi.org/10.1186/s40170-022-00279-8
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!