Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis

Abstract Ulcerative colitis (UC) is associated with epithelial metabolic derangements which exacerbate gut inflammation. Here, we develop colon organoid (colonoid) lines from pediatric patients with endoscopically active UC, inactive UC, and those without intestinal inflammation to interrogate funct...

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Detalhes bibliográficos

Principais autores:	Babajide A. Ojo, Ying Zhu, Lyong Heo, Sejal R. Fox, Yanli Qiao, Amanda Waddell, Maria E. Moreno-Fernandez, Marielle Gibson, Tracy Tran, Ashley L. Dunn, Essam I. A. Elknawy, Neetu Saini, Javier A. López-Rivera, Senad Divanovic, Yuqin Dai, Vinicio A. de Jesus Perez, Michael J. Rosen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-12-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-65988-2
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