Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis

Abstract Ulcerative colitis (UC) is associated with epithelial metabolic derangements which exacerbate gut inflammation. Here, we develop colon organoid (colonoid) lines from pediatric patients with endoscopically active UC, inactive UC, and those without intestinal inflammation to interrogate funct...

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Autori principali:	Babajide A. Ojo, Ying Zhu, Lyong Heo, Sejal R. Fox, Yanli Qiao, Amanda Waddell, Maria E. Moreno-Fernandez, Marielle Gibson, Tracy Tran, Ashley L. Dunn, Essam I. A. Elknawy, Neetu Saini, Javier A. López-Rivera, Senad Divanovic, Yuqin Dai, Vinicio A. de Jesus Perez, Michael J. Rosen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-12-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-025-65988-2
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