Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism[S]

Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol and ceramide. Increased ceramide levels are prese...

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Hlavní autoři:	Rajesh K. Singh, Abigail S. Haka, Alexandria Brumfield, Inna Grosheva, Priya Bhardwaj, Harvey F. Chin, Yuquan Xiong, Timothy Hla, Frederick R. Maxfield
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2017-10-01
Edice:	Journal of Lipid Research
Témata:	atherosclerosis extracellular hydrolysis foam cells lipid and lipoprotein metabolism macrophages
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0022227520335689
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