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AAMP promotes colorectal cancer metastasis by suppressing SMURF2-mediated ubiquitination and degradation of RhoA

Metastasis is considered the leading cause of cancer death due to the limited possibilities to therapeutically target this process. How the ubiquitination machinery contributes to metastasis remains underexplored. Angio-associated migratory cell protein (AAMP), a ubiquitously expressed protein invol...

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Principais autores: Yuhui Wu, Bofang Liu, Weiqiang Lin, Rongjie Zhao, Weidong Han, Jiansheng Xie
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-12-01
Serier:Molecular Therapy: Oncolytics
Fag:
AAMP
colorectal cancer
metastasis
RhoA
SMURF2
ubiquitination
Online adgang:http://www.sciencedirect.com/science/article/pii/S237277052100156X
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