Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism[S]

Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol and ceramide. Increased ceramide levels are prese...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Rajesh K. Singh, Abigail S. Haka, Alexandria Brumfield, Inna Grosheva, Priya Bhardwaj, Harvey F. Chin, Yuquan Xiong, Timothy Hla, Frederick R. Maxfield
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2017-10-01
Цуврал:	Journal of Lipid Research
Нөхцлүүд:	atherosclerosis extracellular hydrolysis foam cells lipid and lipoprotein metabolism macrophages
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S0022227520335689
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!