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Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Summary: Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R...

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Wedi'i Gadw mewn:
Prif Awduron: Tito Borner, Jayme L. Workinger, Ian C. Tinsley, Samantha M. Fortin, Lauren M. Stein, Oleg G. Chepurny, George G. Holz, Aleksandra J. Wierzba, Dorota Gryko, Ebba Nexø, Evan D. Shaulson, Ankur Bamezai, Valentina A. Rodriguez Da Silva, Bart C. De Jonghe, Matthew R. Hayes, Robert P. Doyle
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020-06-01
Cyfres:Cell Reports
Pynciau:
GLP-1 agonist
cobinamide
diabetes
musk shrew
emesis
hypophagia
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2211124720307488
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