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Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Summary: Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R...

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Principais autores: Tito Borner, Jayme L. Workinger, Ian C. Tinsley, Samantha M. Fortin, Lauren M. Stein, Oleg G. Chepurny, George G. Holz, Aleksandra J. Wierzba, Dorota Gryko, Ebba Nexø, Evan D. Shaulson, Ankur Bamezai, Valentina A. Rodriguez Da Silva, Bart C. De Jonghe, Matthew R. Hayes, Robert P. Doyle
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-06-01
Serier:Cell Reports
Fag:
GLP-1 agonist
cobinamide
diabetes
musk shrew
emesis
hypophagia
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124720307488
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