Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Summary: Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R...

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主要な著者:	Tito Borner, Jayme L. Workinger, Ian C. Tinsley, Samantha M. Fortin, Lauren M. Stein, Oleg G. Chepurny, George G. Holz, Aleksandra J. Wierzba, Dorota Gryko, Ebba Nexø, Evan D. Shaulson, Ankur Bamezai, Valentina A. Rodriguez Da Silva, Bart C. De Jonghe, Matthew R. Hayes, Robert P. Doyle
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2020-06-01
シリーズ:	Cell Reports
主題:	GLP-1 agonist cobinamide diabetes musk shrew emesis hypophagia
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124720307488
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