Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Summary: Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R...

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Huvudupphov:	Tito Borner, Jayme L. Workinger, Ian C. Tinsley, Samantha M. Fortin, Lauren M. Stein, Oleg G. Chepurny, George G. Holz, Aleksandra J. Wierzba, Dorota Gryko, Ebba Nexø, Evan D. Shaulson, Ankur Bamezai, Valentina A. Rodriguez Da Silva, Bart C. De Jonghe, Matthew R. Hayes, Robert P. Doyle
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2020-06-01
Serie:	Cell Reports
Ämnen:	GLP-1 agonist cobinamide diabetes musk shrew emesis hypophagia
Länkar:	http://www.sciencedirect.com/science/article/pii/S2211124720307488
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