Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Summary: Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R...

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Hlavní autoři:	Tito Borner, Jayme L. Workinger, Ian C. Tinsley, Samantha M. Fortin, Lauren M. Stein, Oleg G. Chepurny, George G. Holz, Aleksandra J. Wierzba, Dorota Gryko, Ebba Nexø, Evan D. Shaulson, Ankur Bamezai, Valentina A. Rodriguez Da Silva, Bart C. De Jonghe, Matthew R. Hayes, Robert P. Doyle
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2020-06-01
Edice:	Cell Reports
Témata:	GLP-1 agonist cobinamide diabetes musk shrew emesis hypophagia
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124720307488
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