Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter

Abstract In this report, we describe the development of a modified adeno‐associated virus (AAV) capsid and promoter for transduction of retinal ON‐bipolar cells. The bipolar cells, which are post‐synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research. I...

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Bibliografische Detailangaben

Hauptverfasser:	Therese Cronin, Luk H Vandenberghe, Péter Hantz, Josephine Juttner, Andreas Reimann, Ágota–Enikő Kacsó, Rachel M Huckfeldt, Volker Busskamp, Hubertus Kohler, Pamela S Lagali, Botond Roska, Jean Bennett
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2014-08-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	adeno‐associated virus capsid library multi‐electrode array optogenetics promoter optimization
Online-Zugang:	https://doi.org/10.15252/emmm.201404077
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