Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus

The multi-attribute method (MAM), a mass spectrometry technique for quantifying amino acid modifications at the peptide level, is becoming a prominent analytical tool in the development of biotherapeutics. The method has promise for adeno-associated virus (AAV) therapeutics, where capsid protein mod...

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Principais autores:	Thomas W. Powers, Shawn Mariani, Halyna Narepekha, Daniel Ryan, Savita Sankar, Thomas F. Lerch
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-09-01
סדרה:	Molecular Therapy: Methods & Clinical Development
נושאים:	adeno-associated virus, AAV multi-attribute method gene therapy capsid deamidation capsid modifications
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S232905012500155X
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