Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus

The multi-attribute method (MAM), a mass spectrometry technique for quantifying amino acid modifications at the peptide level, is becoming a prominent analytical tool in the development of biotherapeutics. The method has promise for adeno-associated virus (AAV) therapeutics, where capsid protein mod...

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Bibliografski detalji

Glavni autori:	Thomas W. Powers, Shawn Mariani, Halyna Narepekha, Daniel Ryan, Savita Sankar, Thomas F. Lerch
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-09-01
Serija:	Molecular Therapy: Methods & Clinical Development
Teme:	adeno-associated virus, AAV multi-attribute method gene therapy capsid deamidation capsid modifications
Online pristup:	http://www.sciencedirect.com/science/article/pii/S232905012500155X
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