Methodological validation of a cryo-TEM-based detection method for empty capsid ratio in recombinant adeno-associated virus

Recombinant adeno-associated virus (rAAV) is one of the most promising vectors for gene therapy. It consists of a protein capsid that encapsulates the genetic material. However, during the production process, except for the full particles containing the genome, a variety of types of particles are al...

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Hlavní autoři:	Lingyi Xu, Jinhuan Chen, Wei Zhu, Yaokun Zhao, Fangfang Zheng, Rong Du, Yuwei Jiang, Yidan Yang, Yuanyuan Chen, Yuanshu Dong, Zhengxi Zhang, Yong Tong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-03-01
Edice:	Biochemistry and Biophysics Reports
Témata:	Cryo-TEM rAAV Empty capsid ratio Methodological validation
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2405580825004844
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