Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration.

Doppel protein (Dpl) is a paralog of the cellular form of the prion protein (PrP(C)), together sharing common structural and biochemical properties. Unlike PrP(C), which is abundantly expressed throughout the central nervous system (CNS), Dpl protein expression is not detectable in the CNS. Interest...

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Principais autores:	Stefano Benvegnù, Diego Franciotta, Josh Sussman, Angela Bachi, Elisabetta Zardini, Paola Torreri, Cedric Govaerts, Salvatore Pizzo, Giuseppe Legname
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2009-06-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC2693666?pdf=render
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