Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD

Abstract pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-13C2]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tum...

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Detalhes bibliográficos

Principais autores:	Martin Grashei, Pascal Wodtke, Jason G. Skinner, Sandra Sühnel, Nadine Setzer, Thomas Metzler, Sebastian Gulde, Mihyun Park, Daniela Witt, Hermine Mohr, Christian Hundshammer, Nicole Strittmatter, Natalia S. Pellegata, Katja Steiger, Franz Schilling
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-08-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-023-40747-3
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