pH Dependence of <i>T</i>₂ for Hyperpolarizable ¹³C-Labelled Small Molecules Enables Spatially Resolved pH Measurement by Magnetic Resonance Imaging

Hyperpolarized ¹³C magnetic resonance imaging often uses spin-echo-based pulse sequences that are sensitive to the transverse relaxation time <i>T</i>₂. In this context, local <i>T</i>₂-changes might introduce a quantification bias to imaging biomarkers. Here, we inv...

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Detalhes bibliográficos

Principais autores:	Martin Grashei, Christian Hundshammer, Frits H. A. van Heijster, Geoffrey J. Topping, Franz Schilling
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-04-01
coleção:	Pharmaceuticals
Assuntos:	<i>T</i><sub>2</sub> relaxation time constant pH [1-<sup>13</sup>C]pyruvate [1-<sup>13</sup>C]acetate <sup>13</sup>C-labeled biomolecules hyperpolarization
Acesso em linha:	https://www.mdpi.com/1424-8247/14/4/327
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