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In-Cell Determination of Lactate Dehydrogenase Activity in a Luminal Breast Cancer Model – <i>ex vivo</i> Investigation of Excised Xenograft Tumor Slices Using dDNP Hyperpolarized [1-<sup>13</sup>C]pyruvate

[1-<sup>13</sup>C]pyruvate, the most widely used compound in dissolution-dynamic nuclear polarization (dDNP) magnetic resonance (MR), enables the visualization of lactate dehydrogenase (LDH) activity. This activity had been demonstrated in a wide variety of cancer models, ranging from cultured cells...

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Main Authors: Yael Adler-Levy, Atara Nardi-Schreiber, Talia Harris, David Shaul, Sivaranjan Uppala, Gal Sapir, Naama Lev-Cohain, Jacob Sosna, Shraga Nahum Goldberg, J. Moshe Gomori, Rachel Katz-Brull
Format: Artigo
Language:Inglês
Published: MDPI AG 2019-05-01
Series:Sensors
Subjects:
LDH
<sup>13</sup>C-NMR
hyperpolarization
magnetic resonance
breast cancer
precision-cut tissue slices
Online Access:https://www.mdpi.com/1424-8220/19/9/2089
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