Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Abstract Background The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD). However, the contribution of the classical complement pathway towards the progression of retin...

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Principais autores:	Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2018-08-01
Serija:	Molecular Neurodegeneration
Teme:	Macrophages Microglia Complement system Classical pathway C1q Inflammasome
Online dostop:	http://link.springer.com/article/10.1186/s13024-018-0278-0
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