Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Abstract Background The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD). However, the contribution of the classical complement pathway towards the progression of retin...

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Autori principali:	Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2018-08-01
Serie:	Molecular Neurodegeneration
Soggetti:	Macrophages Microglia Complement system Classical pathway C1q Inflammasome
Accesso online:	http://link.springer.com/article/10.1186/s13024-018-0278-0
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