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Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Abstract Background The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD). However, the contribution of the classical complement pathway towards the progression of retin...

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Principais autores: Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-08-01
coleção:Molecular Neurodegeneration
Assuntos:
Macrophages
Microglia
Complement system
Classical pathway
C1q
Inflammasome
Acesso em linha:http://link.springer.com/article/10.1186/s13024-018-0278-0
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