Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1) and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 in mouse models of Alzheimer's disease have opposing effects on amyloid-β and tau pathologies raising concerns about the b...

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Автори:	Suzanne E. Hickman, Elizabeth K. Allison, Uwanda Coleman, Nathan D. Kingery-Gallagher, Joseph El Khoury
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2019-12-01
Серія:	Frontiers in Immunology
Предмети:	microglia Alzheimer's disease CX3CR1 Aβ-degrading enzymes fractalkine chemokines
Онлайн доступ:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02780/full
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