Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1) and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 in mouse models of Alzheimer's disease have opposing effects on amyloid-β and tau pathologies raising concerns about the b...

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Auteurs principaux:	Suzanne E. Hickman, Elizabeth K. Allison, Uwanda Coleman, Nathan D. Kingery-Gallagher, Joseph El Khoury
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2019-12-01
Collection:	Frontiers in Immunology
Sujets:	microglia Alzheimer's disease CX3CR1 Aβ-degrading enzymes fractalkine chemokines
Accès en ligne:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02780/full
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