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CD34+CLDN5+ tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma

Introduction: The heterogeneity of hepatocellular carcinoma (HCC) is linked to tumor malignancy and poor prognosis. Nevertheless, the precise mechanisms underlying the development of the cholangiocellular phenotype (CCA) within HCC remain unclear. Emerging studies support that the cross-talk among t...

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Principais autores: Xin-yu Zhu, Wen-ting Liu, Xiao-juan Hou, Chen Zong, Wei Yu, Zhe-min Shen, Shu-ping Qu, Min Tao, Meng-meng Xue, Dao-yu Zhou, Hao-ran Bai, Lu Gao, Jing-hua Jiang, Qiu-dong Zhao, Li-xin Wei, Xue Yang, Zhi-peng Han, Li Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-10-01
Serier:Journal of Advanced Research
Fag:
Single-cell RNA sequencing
Tumor associated senescent endothelial cells
Cholangiocellular phenotype
Mesenchymal stem cells
Online adgang:http://www.sciencedirect.com/science/article/pii/S2090123224005642
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