Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma

Abstract Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant I...

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Principais autores:	William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, PEACE consortium, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M. Flanagan, Peter Van Loo
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2025-11-01
סדרה:	Genome Biology
נושאים:	Chondrosarcoma Cancer evolution IDH1 IDH2 Metastasis Bone tumor
גישה מקוונת:	https://doi.org/10.1186/s13059-025-03812-2
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