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Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma

Abstract Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant I...

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Hoofdauteurs: William Cross, Iben Lyskjær, Christopher Davies, Abigail Bunkum, Ana Maia Rocha, Tom Lesluyes, Fernanda Amary, Roberto Tirabosco, Cristina Naceur-Lombardelli, PEACE consortium, Mariam Jamal-Hanjani, Charles Swanton, Nischalan Pillay, Simone Zaccaria, Adrienne M. Flanagan, Peter Van Loo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2025-11-01
Reeks:Genome Biology
Onderwerpen:
Chondrosarcoma
Cancer evolution
IDH1
IDH2
Metastasis
Bone tumor
Online toegang:https://doi.org/10.1186/s13059-025-03812-2
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