CD34+CLDN5+ tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma

Introduction: The heterogeneity of hepatocellular carcinoma (HCC) is linked to tumor malignancy and poor prognosis. Nevertheless, the precise mechanisms underlying the development of the cholangiocellular phenotype (CCA) within HCC remain unclear. Emerging studies support that the cross-talk among t...

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Hauptverfasser:	Xin-yu Zhu, Wen-ting Liu, Xiao-juan Hou, Chen Zong, Wei Yu, Zhe-min Shen, Shu-ping Qu, Min Tao, Meng-meng Xue, Dao-yu Zhou, Hao-ran Bai, Lu Gao, Jing-hua Jiang, Qiu-dong Zhao, Li-xin Wei, Xue Yang, Zhi-peng Han, Li Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-10-01
Schriftenreihe:	Journal of Advanced Research
Schlagworte:	Single-cell RNA sequencing Tumor associated senescent endothelial cells Cholangiocellular phenotype Mesenchymal stem cells
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2090123224005642
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