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Retinal fingerprints of ALS in patients: Ganglion cell apoptosis and TDP-43/p62 misplacement

IntroductionAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neuron function. Although ophthalmic deficits are not considered a classic symptom of ALS, recent studies suggest that changes in retinal cells, similar to those in the...

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Main Authors: Natalia Pediconi, Ylenia Gigante, Silvia Cama, Martina Pitea, Lorenza Mautone, Giancarlo Ruocco, Silvia Ghirga, Silvia Di Angelantonio
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
retina
ALS
neurodegeneration
biomarkers
protein inclusions
neurons
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1110520/full
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