Mathematical modeling suggests 14-3-3 proteins modulate RAF paradoxical activation.

RAF inhibitor "paradoxical activation" (PA) is a phenomenon where RAF kinase inhibitors increase RAF kinase signaling. Through mathematical modeling and experimental data analysis, we recently demonstrated that the combination of conformational autoinhibition (CA) with the disruption of CA by RAF in...

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Bibliografiske detaljer

Principais autores:	Gaurav Mendiratta, Kodye Abbott, Yao-Cheng Li, Jingting Yu, Peter Carlip, Melinda Tong, Jianfeng Huang, Maxim N Shokhirev, Thomas McFall, Geoffrey M Wahl, Edward C Stites
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2025-08-01
Serier:	PLoS Computational Biology
Online adgang:	https://doi.org/10.1371/journal.pcbi.1013297
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