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PH domain-mediated autoinhibition and oncogenic activation of Akt

Akt is a Ser/Thr protein kinase that plays a central role in metabolism and cancer. Regulation of Akt’s activity involves an autoinhibitory intramolecular interaction between its pleckstrin homology (PH) domain and its kinase domain that can be relieved by C-tail phosphorylation. PH domain mutant E1...

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Principais autores: Hwan Bae, Thibault Viennet, Eunyoung Park, Nam Chu, Antonieta Salguero, Michael J Eck, Haribabu Arthanari, Philip A Cole
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2022-08-01
coleção:eLife
Assuntos:
protein kinase
NMR
protein semisynthesis
enzymes
phosphorylation
Acesso em linha:https://elifesciences.org/articles/80148
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