Mathematical modeling suggests 14-3-3 proteins modulate RAF paradoxical activation.
RAF inhibitor "paradoxical activation" (PA) is a phenomenon where RAF kinase inhibitors increase RAF kinase signaling. Through mathematical modeling and experimental data analysis, we recently demonstrated that the combination of conformational autoinhibition (CA) with the disruption of CA by RAF in...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science (PLoS)
2025-08-01
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| Col·lecció: | PLoS Computational Biology |
| Accés en línia: | https://doi.org/10.1371/journal.pcbi.1013297 |
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