LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens

ABSTRACT The problem of multidrug resistance in serious Gram-negative bacterial pathogens has escalated so severely that new cellular targets and pathways need to be exploited to avoid many of the preexisting antibiotic resistance mechanisms that are rapidly disseminating to new strains. The discove...

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Hauptverfasser:	Andrew P. Tomaras, Craig J. McPherson, Michael Kuhn, Arlene Carifa, Lisa Mullins, David George, Charlene Desbonnet, Tess M. Eidem, Justin I. Montgomery, Matthew F. Brown, Usa Reilly, Alita A. Miller, John P. O’Donnell
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2014-10-01
Schriftenreihe:	mBio
Online-Zugang:	https://journals.asm.org/doi/10.1128/mBio.01551-14
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