LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens

ABSTRACT The problem of multidrug resistance in serious Gram-negative bacterial pathogens has escalated so severely that new cellular targets and pathways need to be exploited to avoid many of the preexisting antibiotic resistance mechanisms that are rapidly disseminating to new strains. The discove...

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Hlavní autoři:	Andrew P. Tomaras, Craig J. McPherson, Michael Kuhn, Arlene Carifa, Lisa Mullins, David George, Charlene Desbonnet, Tess M. Eidem, Justin I. Montgomery, Matthew F. Brown, Usa Reilly, Alita A. Miller, John P. O’Donnell
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2014-10-01
Edice:	mBio
On-line přístup:	https://journals.asm.org/doi/10.1128/mBio.01551-14
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