TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on In Vitro Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae

ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent threat to public health requiring the development of novel therapies. TP0586532 is a novel non-hydroxamate LpxC inhibitor that inhibits the synthesis of lipopolysaccharides, which are components of the outer membranes of Gram-negat...

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Autores principales:	Ippei Yoshida, Iichiro Takata, Kiyoko Fujita, Hajime Takashima, Hiroyuki Sugiyama
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology 2022-06-01
Colección:	Microbiology Spectrum
Materias:	carbapenem-resistant Enterobacteriaceae LpxC inhibitor TP0586532 combination meropenem permeability
Acceso en línea:	https://journals.asm.org/doi/10.1128/spectrum.00828-22
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