Biology of novel LpxC inhibitors for Neisseria gonorrhoeae informs strategy for therapeutic innovation
ABSTRACT Historically, LpxC inhibitors, which target the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase catalyzing the rate-limiting step in lipid A biosynthesis, have a hydroxamate zinc-chelating head group that targets the active site and can participate in non-specific metal chela...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2026-02-01
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| coleção: | Microbiology Spectrum |
| Assuntos: | |
| Acesso em linha: | https://journals.asm.org/doi/10.1128/spectrum.02543-25 |
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