Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

Mutations in the human WDR81 gene result in severe microcephaly. Carpentieri et al. show that mutation of WDR81, a gene coding for an endosomal regulator, alters intracellular processing of the EGF receptor, leading to reduced proliferation rates of neuronal progenitors and to microcephaly.

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Detaylı Bibliyografya
Asıl Yazarlar:	Jacopo A. Carpentieri, Amandine Di Cicco, Marusa Lampic, David Andreau, Laurence Del Maestro, Fatima El Marjou, Laure Coquand, Nadia Bahi-Buisson, Jean-Baptiste Brault, Alexandre D. Baffet
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Nature Portfolio 2022-01-01
Seri Bilgileri:	Nature Communications
Online Erişim:	https://doi.org/10.1038/s41467-021-27705-7
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

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