Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

Mutations in the human WDR81 gene result in severe microcephaly. Carpentieri et al. show that mutation of WDR81, a gene coding for an endosomal regulator, alters intracellular processing of the EGF receptor, leading to reduced proliferation rates of neuronal progenitors and to microcephaly.

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Bibliografiska uppgifter
Huvudupphov:	Jacopo A. Carpentieri, Amandine Di Cicco, Marusa Lampic, David Andreau, Laurence Del Maestro, Fatima El Marjou, Laure Coquand, Nadia Bahi-Buisson, Jean-Baptiste Brault, Alexandre D. Baffet
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2022-01-01
Serie:	Nature Communications
Länkar:	https://doi.org/10.1038/s41467-021-27705-7
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Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

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