Ribonucleotide reductases in cancer: Mechanisms, clinical progress, and prospects
Ribonucleotide reductase (RNR) catalyzes the rate limiting conversion of ribonucleotides to deoxyribonucleotides (dNTPs), essential for DNA synthesis and repair. Aberrant RNR activity in cancer drives genomic instability, promoting tumor proliferation, metastasis and resistance to therapeutic interv...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
KeAi Communications Co., Ltd.
2025-09-01
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| Serier: | Cell Investigation |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S3050538025000286 |
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