Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells

Abstract Background Ewing’s sarcoma is a childhood bone and soft tissue cancer with poor prognosis. Treatment outcomes for Ewing’s sarcoma patients have improved only modestly over the past decades, making the development of new treatment strategies paramount. In this study, the combined targeting o...

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Detalhes bibliográficos

Principais autores:	Judy Ziener, Julián Andrés Henao-Restrepo, Johanna Leonhardi, Max-Johann Sturm, Sabine Becker, Diana M. Morales-Prieto, Till Milde, James F. Beck, Jürgen Sonnemann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
coleção:	BMC Cancer
Assuntos:	Ewing’s sarcoma Targeted therapy Ribonucleotide reductase WEE1 PARP Triapine
Acesso em linha:	https://doi.org/10.1186/s12885-025-13691-2
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