Ribonucleotide reductases in cancer: Mechanisms, clinical progress, and prospects

Ribonucleotide reductase (RNR) catalyzes the rate limiting conversion of ribonucleotides to deoxyribonucleotides (dNTPs), essential for DNA synthesis and repair. Aberrant RNR activity in cancer drives genomic instability, promoting tumor proliferation, metastasis and resistance to therapeutic interv...

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Bibliographic Details

Main Authors:	Simin Chen, Yi Huang, Shida Zhang, Junyi Zhang, Cheng Chen, Guo Chen, Danyang Zhou
Format:	Artigo
Language:	Inglês
Published:	KeAi Communications Co., Ltd. 2025-09-01
Series:	Cell Investigation
Subjects:	DNA synthesis Ribonucleotide reductases Ribonucleotide reductase inhibitors Cancer chemotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S3050538025000286
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