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TCA cycle-derived oncometabolites in cancer and the immune microenvironment

Abstract Oncometabolites are aberrant metabolic byproducts that arise from mutations in enzymes of the tricarboxylic acid (TCA) cycle or related metabolic pathways and play central roles in tumor progression and immune evasion. Among these, 2-hydroxyglutarate (2-HG), succinate, and fumarate are the...

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書誌詳細
主要な著者: Shukla Sarkar, Chien-I Chang, Jussekia Jean, Meng-Ju Wu
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2025-09-01
シリーズ:Journal of Biomedical Science
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オンライン・アクセス:https://doi.org/10.1186/s12929-025-01186-y
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