TCA cycle-derived oncometabolites in cancer and the immune microenvironment

Abstract Oncometabolites are aberrant metabolic byproducts that arise from mutations in enzymes of the tricarboxylic acid (TCA) cycle or related metabolic pathways and play central roles in tumor progression and immune evasion. Among these, 2-hydroxyglutarate (2-HG), succinate, and fumarate are the...

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Autors principals:	Shukla Sarkar, Chien-I Chang, Jussekia Jean, Meng-Ju Wu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-09-01
Col·lecció:	Journal of Biomedical Science
Matèries:	Oncometabolites 2-hydroxyglutarate Succinate Fumarate Itaconate α-ketoglutarate
Accés en línia:	https://doi.org/10.1186/s12929-025-01186-y
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