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Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs

Abstract Background Microbial infections, particularly those caused by rhinovirus (RV) and respiratory syncytial virus (RSV), are major triggers for asthma exacerbations. These viruses activate toll-like receptors (TLRs), initiating an innate immune response. To better understand microbial-induced a...

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Autori principali: Yujiao Xiang, Jielu Liu, Mu Nie, Gunnar Nilsson, Jesper Säfholm, Mikael Adner
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-11-01
Serie:Respiratory Research
Soggetti:
Respiratory infections
Poly (I:C)
Lipopolysaccharide (LPS)
Imiquimod
Inflammation
Mast cell
Accesso online:https://doi.org/10.1186/s12931-024-03050-3
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