ID93 + GLA-3M-052-LS vaccine candidate administered by heterologous routes improves BCG efficacy against TB

BackgroundNew vaccine approaches are needed against tuberculosis (TB). We sought to optimize mucosal immunogenicity and protective efficacy by modulating the adjuvant component and route of immunization of a next-generation TB vaccine using the recombinant TB vaccine antigen (Ag) ID93.MethodsID93-sp...

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Главные авторы:	Emily Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine Farber Jennewein, Devin S. Brandt, Susan Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi B. Torrelles, Gillian Beamer, Christopher B. Fox
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-05-01
Серии:	Frontiers in Immunology
Предметы:	adjuvant formulation immunization route intranasal vaccine mucosal immunity tuberculosis vaccine
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797767/full
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