ID93 + GLA-3M-052-LS vaccine candidate administered by heterologous routes improves BCG efficacy against TB

BackgroundNew vaccine approaches are needed against tuberculosis (TB). We sought to optimize mucosal immunogenicity and protective efficacy by modulating the adjuvant component and route of immunization of a next-generation TB vaccine using the recombinant TB vaccine antigen (Ag) ID93.MethodsID93-sp...

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主要な著者:	Emily Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine Farber Jennewein, Devin S. Brandt, Susan Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi B. Torrelles, Gillian Beamer, Christopher B. Fox
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-05-01
シリーズ:	Frontiers in Immunology
主題:	adjuvant formulation immunization route intranasal vaccine mucosal immunity tuberculosis vaccine
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797767/full
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