ID93 + GLA-3M-052-LS vaccine candidate administered by heterologous routes improves BCG efficacy against TB

BackgroundNew vaccine approaches are needed against tuberculosis (TB). We sought to optimize mucosal immunogenicity and protective efficacy by modulating the adjuvant component and route of immunization of a next-generation TB vaccine using the recombinant TB vaccine antigen (Ag) ID93.MethodsID93-sp...

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Autors principals:	Emily Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine Farber Jennewein, Devin S. Brandt, Susan Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi B. Torrelles, Gillian Beamer, Christopher B. Fox
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-05-01
Col·lecció:	Frontiers in Immunology
Matèries:	adjuvant formulation immunization route intranasal vaccine mucosal immunity tuberculosis vaccine
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797767/full
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