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ID93 + GLA-3M-052-LS vaccine candidate administered by heterologous routes improves BCG efficacy against TB

BackgroundNew vaccine approaches are needed against tuberculosis (TB). We sought to optimize mucosal immunogenicity and protective efficacy by modulating the adjuvant component and route of immunization of a next-generation TB vaccine using the recombinant TB vaccine antigen (Ag) ID93.MethodsID93-sp...

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Principais autores: Emily Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine Farber Jennewein, Devin S. Brandt, Susan Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi B. Torrelles, Gillian Beamer, Christopher B. Fox
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Immunology
Assuntos:
adjuvant formulation
immunization route
intranasal vaccine
mucosal immunity
tuberculosis vaccine
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797767/full
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